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Photomedicine and Laser Surgery, Volume 27, Number 2, 2009
Case Report
Photodynamic Therapy Can Be Effective as a Treatment for Herpes Simplex Labialis
Juliana Marotti, D.D.S.,1
Ana Cecília
Correa Aranha, D.D.S., Ms.C., Ph.D.,2, Carlos De Paula Eduardo, D.D.S., Ms.C.,
Ph.D.,2 and Martha Simões
Ribeiro, Ph.D.3
Abstract
Background Data and Objective:
Herpes is a common
infectious disease that is caused by human herpesviruses. Several treatments have been proposed, but
none of them prevent reactivation of the virus. This article
describes the use of photodynamic therapy (PDT) as a
treatment for herpes lesions, and reports on four cases.
Materials and Methods: PDT was used as an
adjuvant therapy for the treatment of herpes labialis in
four patients. A special type of 0.01% (m/V) of methylene
blue solution was applied to the vesicular stage of
herpesviral disease and the lesions were irradiated with
laser energy (wavelength 660 nm, energy density 120 J/cm2,
output power of 40 mW, 2 min per point, 4.8 J of
energy/point, at four points). After 24 h the patients returned and phototherapy was repeated with
the same equipment, this time with 3.8 J/cm2
and 15 mW, for a total dose of 0.6 J. The same procedure
was repeated 72 h and 1 wk later.
Results: Treatment with
low-level laser therapy can be considered as an option in
the treatment of herpes labialis, and decreases the frequency of vesicle
recurrence and provides comfort for patients. No significant
acute side effects were noted and the lesions
healed rapidly.
Conclusion: Treatment of herpes
labialis with PDT was effective, had no side effects, and
when associated with laser phototherapy, accelerated the healing process.
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